Lab Publications

       For the complete bibliography of Springer papers, see the Springer CV

Publications from Dr. Springer and lab personnel before they arrived at UCSF are not included in the following list, and can be found in individuals' CVs if available in the Lab Personnel page.  Links for individual publications are Medline links; your ability to access the papers will depend on your institutional or personal subscription status.  This prevents us from running afoul of copyright laws.  If you cannot access a needed paper, please contact us to request a reprint.

 
Springer Lab publications (at UCSF)

(Does not include Springer papers prior to UCSF)

Li, X., Tjwa, M., Van Hove, I., Enholm, B., Neven E., Paavonen, K., Jeltsch, M., Diez Juan, T., Sievers, R.E., Chorianopoulos, E., Wada, H., Vanwildemeersch, M., Noel, A., Foidart, J.-M., Springer, M.L., von Degenfeld, G., Dewerchin, M., Blau, H.M., Alitalo, K., Eriksson, U., Carmeliet, P. and Moons, L.  Re-evaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium.  Arterioscler. Thromb. Vasc. Biol., Epub ahead of print, May 29, 2008.   |  Epub

Heiss, C., Amabile, N., Lee, A.C., Real, W.M., Schick, S., Lao, D., Wong, M.L., Jahn, S., Angeli, F.S., Minasi, P., Springer, M.L., Hammond, S.K., Glantz, S.A., Grossman, W., Balmes, J.R., and Yeghiazarians, Y.  (2008).  Second hand smoke causes acute vascular injury, and mobilization of dysfunctional endothelial progenitor cells.  J Amer Coll Cardiol. 51:1760-1771.  (Commentary in ibid., 51:1772-1774)   |  Medline

Springer, M.L.  (2008).  Living both music and medicine: Where the two practices intersect. (One of several sections.)  San Francisco Medicine 81(2):38-39.   |  Free download (entire issue)

Heiss, C., Wong, M.L., Block, V.I., Lao, D., Real, W.M., Yeghiazarians, Y., Lee, R.J., and Springer, M.L.    (2008).  Pleiotrophin induces nitric oxide dependent migration of endothelial progenitor cells.  J Cell Physiol 215:366-373.   |  Medline

Heiss, C., Sievers, R.E., Amabile, N., Momma, T.Y., Chen, Q., Natarajan, S., Yeghiazarians, Y., and Springer, M.L.  (2008).  In vivo measurement of flow-mediated vasodilation in living rats using high resolution ultrasound.   Am J Physiol Heart Circ Physiol 294:H1086-H1093   |  Free download

Springer, M.L., Banfi, A., Ye, J., von Degenfeld, G., Kraft, P.E., Saini, S.A., Kapasi, N.K., and Blau, H.M.  (2007).  Localization of vascular response to VEGF is not dependent on heparin binding.  FASEB J 21:2074-2085.    |  Medline

Takagawa, J., Zhang, Y., Wong, M.L., Sievers, R.E., Kapasi, N.K., Wang, Y., Yeghiazarians, Y., Lee, R.J., Grossman, W., and Springer, M.L.  (2007).  Myocardial infarct size measurement in the mouse chronic infarction model: Comparison of area- and length-based approaches.  J Appl Physiol 102:2104-2111.   |  Medline

Zhang, Y., Takagawa, J., Sievers, R.E., Khan, M.F., Viswanathan, M.N., Springer, M.L., Foster, E., and Yeghiazarians, Y.  (2007).  Validation of the wall motion score and myocardial performance indices as novel techniques to assess left ventricular function in mice post myocardial infarction.  Am J Physiol Heart Circ Physiol 292:H1187-H1192.    |  Medline

Springer, M.L. (2006).  A balancing act: Therapeutic approaches to the modulation of angiogenesis.  Current Opinion in Investigational Drugs 7:243-250.   |  Medline

Kamba, T., Tam, B.Y.Y., Hashizume, H., Haskell, A., Sennino, B., Mancuso, M.R., Norberg, S.M., O'Brien S, M., Davis, R.B., Gowen, L.C., Anderson, K.D., Thurston, G., Joho, S., Springer, M.L., Kuo, C.J., and McDonald, D.M. (2006). VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol 290:H560-H576.  |  Medline

von Degenfeld, G., Banfi, A., Springer, M.L., Jacobi, J., Ozawa, C.R., Merchant, M.J., Cooke, J.P., and Blau, H.M.  (2006).  Microenvironmental concentration of VEGF is critical to stable and functional vessel growth in ischemia. FASEB J 20:2657-2659.   |  Medline

Springer, M.L., Sievers, R.E., Viswanathan, M.N., Yee, M.S., Foster, E., Grossman, W., and Yeghiazarians, Y. (2005). Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography. Am J Physiol Heart Circ Physiol 289:H1307-H1314.   |  Medline

Recent abstracts/posters

Heiss, C., Chen, Q., Su, R., Sievers, R.E., Schick, S.F., Glantz, S.A., Yeghiazarians, Y., and Springer, M.L. (2008)  A physiological model for measurement of secondhand smoke-induced endothelial dysfunction.  Flight Attendant Medical Research Institute 7th Scientific Symposium, Boston, MA.

Prasad, M., Zhang, Y., Sievers, R.E., Minasi, P., Saini, S.A., Shih, H., Grossman, W., Angeli, F., Springer, M.L., Boyle, A., and Yeghiazarians, Y. (2008)  Bone marrow cell and lysate therapies improve cardiac function post myocardial infarction by angiogenesis early after treatment.  AHA Council on Arteriosclerosis, Thrombosis and Vascular Biology Annual Conference, Atlanta, GA.

Heiss, C., Momma, T.Y., Sievers, R.E., Schroeter, H., Keen, C.L., Yeghiazarians, Y., and Springer, M.L. (2007)  In vivo metabolites of cocoa flavanols increase endothelial vasodilator function in living rats.  3rd International Conference on Polyphenols and Health, Kyoto, Japan.

Rao, R.K., Ye, J., Real, W.M., Springer, M.L., Grossman, W., De Marco, T., and Yeghiazarians, Y. (2007)  Reduced number and function of circulating endothelial progenitor cells in patients with pulmonary arterial hypertension.  International Society for Heart & Lung Transplantation 27th Annual Meeting, San Francisco, CA.

Heiss, C., Schanz, A., Real, W.M., Grossman, W., Yeghiazarians, Y., and Springer, M.L. (2006).  Nitric oxide mediates migration of endothelial cells and circulating progenitor cells through both nitric oxide synthase (NOS)-dependent and NOS-independent processes.   AHA Scientific Sessions, Chicago, IL.

Fang, Q., Wen, G., Blanco-Bose, W.E., Sievers, R.E., Springer, M.L., Blau, H.M., and Lee, R.J. (2006)  Skeletal myoblasts overexpressing connexin 43 form functional gap junctions with adult cardiomyocytes in vitro and in vivo.  AHA Scientific Sessions, Chicago, IL.

Amabile, N., Heiss, C., Real, W.M., Minasi, P., Springer, M.L., McGlothlin, D., Rame, E.J., Grossman, W., De Marco, T., and Yeghiazarians, Y. (2006).  Levels of circulating endothelial microparticles predict hemodynamic severity of untreated pulmonary arterial hypertension.   AHA Scientific Sessions, Chicago, IL.

Zhang, Y., Takagawa, J., Sievers, R.E., Wong, M.L., Heiss, C., Viswanathan, M.N., Kapasi, N.K., Ye, J., Foster, E., Grossman, W., Springer, M.L., and Yeghiazarians, Y. (2006).  Improvement of cardiac function by ultrasound-guided injection of bone marrow cells into mouse myocardium three days post-infarction. AHA Council on Basic Cardiovascular Sciences 3rd Annual Meeting, Keystone, CO.

Key publications from previous incarnations of the vascular laboratory, pre-2004

O'Connell, T. D., Ishizaka, S., Nakamura, A., Swigart, P. M., Rodrigo, M. C., Simpson, G. L., Cotecchia, S., Rokosh, D. G., Grossman, W., Foster, E., and Simpson, P. C. (2003). The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse. J Clin Invest 111, 1783-1791.   |  Medline

Zhu, B. Q., Sievers, R. E., Browne, A. E., Lee, R. J., Chatterjee, K., Grossman, W., Karliner, J. S., and Parmley, W. W. (2003). Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function. J Renin Angiotensin Aldosterone Syst 4, 31-37.   |  Medline

Zhu, B. Q., Sievers, R. E., Browne, A. E., Hillman, R. T., Chair, K., Lee, R. J., Chatterjee, K., Glantz, S. A., and Parmley, W. W. (2002). The renin-angiotensin system does not contribute to the endothelial dysfunction and increased infarct size in rats exposed to second hand smoke. J Renin Angiotensin Aldosterone Syst 3, 54-60.   |  Medline

Nakamura, A., Rokosh, D. G., Paccanaro, M., Yee, R. R., Simpson, P. C., Grossman, W., and Foster, E. (2001). LV systolic performance improves with development of hypertrophy after transverse aortic constriction in mice. Am J Physiol Heart Circ Physiol 281, H1104-H1112.   |  Medline

Zhu, B., Sun, Y., Sievers, R. E., Browne, A. E., Lee, R. J., Chatterjee, K., and Parmley, W. W. (2001). Effects of different durations of pretreatment with losartan on myocardial infarct size, endothelial function, and vascular endothelial growth factor. J Renin Angiotensin Aldosterone Syst 2, 129-133.   |  Medline

Hutchison, S. J., Sievers, R. E., Zhu, B. Q., Sun, Y. P., Stewart, D. J., Parmley, W. W., and Chatterjee, K. (2001). Secondhand tobacco smoke impairs rabbit pulmonary artery endothelium-dependent relaxation. Chest 120, 2004-2012.   |  Medline

Sun, Y. P., Zhu, B. Q., Browne, A. E., Sievers, R. E., Bekker, J. M., Chatterjee, K., Parmley, W. W., and Glantz, S. A. (2001). Nicotine does not influence arterial lipid deposits in rabbits exposed to second-hand smoke. Circulation 104, 810-814.   |  Medline

Zhu, B., Sun, Y., Sievers, R. E., Browne, A. E., Pulukurthy, S., Sudhir, K., Lee, R. J., Chou, T. M., Chatterjee, K., and Parmley, W. W. (2000). Comparative effects of pretreatment with captopril and losartan on cardiovascular protection in a rat model of ischemia-reperfusion. J Am Coll Cardiol 35, 787-795.   |  Medline

Hutchison, S. J., Sudhir, K., Sievers, R. E., Zhu, B. Q., Sun, Y. P., Chou, T. M., Chatterjee, K., Deedwania, P. C., Cooke, J. P., Glantz, S. A., and Parmley, W. W. (1999). Effects of L-arginine on atherogenesis and endothelial dysfunction due to secondhand smoke. Hypertension 34, 44-50.   |  Medline

Zhu, B. Q., Sun, Y. P., Sudhir, K., Sievers, R. E., Browne, A. E., Gao, L., Hutchison, S. J., Chou, T. M., Deedwania, P. C., Chatterjee, K., Glantz, S. A., and Parmley, W. W. (1997). Effects of second-hand smoke and gender on infarct size of young rats exposed in utero and in the neonatal to adolescent period. J Am Coll Cardiol 30, 1878-1885.   |  Medline

Hutchison, S. J., Reitz, M. S., Sudhir, K., Sievers, R. E., Zhu, B. Q., Sun, Y. P., Chou, T. M., Deedwania, P. C., Chatterjee, K., Glantz, S. A., and Parmley, W. W. (1997). Chronic dietary L-arginine prevents endothelial dysfunction secondary to environmental tobacco smoke in normocholesterolemic rabbits. Hypertension 29, 1186-1191.   |  Medline

Hutchison, S. J., Sudhir, K., Chou, T. M., Sievers, R. E., Zhu, B. Q., Sun, Y. P., Deedwania, P. C., Glantz, S. A., Parmley, W. W., and Chatterjee, K. (1997). Testosterone worsens endothelial dysfunction associated with hypercholesterolemia and environmental tobacco smoke exposure in male rabbit aorta. J Am Coll Cardiol 29, 800-807.   |  Medline

Sun, Y. P., Zhu, B. Q., Sievers, R. E., Glantz, S. A., and Parmley, W. W. (1994). Metoprolol does not attenuate atherosclerosis in lipid-fed rabbits exposed to environmental tobacco smoke. Circulation 89, 2260-2265.   |  Medline

Zhu, B. Q., Sun, Y. P., Sievers, R. E., Glantz, S. A., Parmley, W. W., and Wolfe, C. L. (1994). Exposure to environmental tobacco smoke increases myocardial infarct size in rats. Circulation 89, 1282-1290.   |  Medline

Zhu, B. Q., Sun, Y. P., Sievers, R. E., Isenberg, W. M., Moorehead, T. J., and Parmley, W. W. (1994). Effects of etidronate and lovastatin on the regression of atherosclerosis in cholesterol-fed rabbits. Cardiology 85, 370-377.   |  Medline

Sun, Y. P., Zhu, B. Q., Sievers, R. E., Isenberg, W. M., and Parmley, W. W. (1993). Aspirin inhibits platelet activity but does not attenuate experimental atherosclerosis. Am Heart J 125, 79-86.   |  Medline

Zhu, B. Q., Sun, Y. P., Sievers, R. E., Isenberg, W. M., Glantz, S. A., and Parmley, W. W. (1993). Passive smoking increases experimental atherosclerosis in cholesterol-fed rabbits. J Am Coll Cardiol 21, 225-232.   |  Medline

Zhu, B. Q., Sievers, R. E., Sun, Y. P., Isenberg, W. M., and Parmley, W. W. (1992). Effect of lovastatin on suppression and regression of atherosclerosis in lipid-fed rabbits. J Cardiovasc Pharmacol 19, 246-255.   |  Medline

Zhu, B. Q., Sievers, R. E., Isenberg, W. M., Smith, D. L., and Parmley, W. W. (1990). Regression of atherosclerosis in cholesterol-fed rabbits: effects of fish oil and verapamil. J Am Coll Cardiol 15, 231-237.   |  Medline

Sievers, R. E., Schmiedl, U., Wolfe, C. L., Moseley, M. E., Parmley, W. W., Brasch, R. C., and Lipton, M. J. (1989). A model of acute regional myocardial ischemia and reperfusion in the rat. Magn Reson Med 10, 172-181.   |  Medline

Zhu, B. Q., Smith, D. L., Sievers, R. E., Isenberg, W. M., and Parmley, W. W. (1988). Inhibition of atherosclerosis by fish oil in cholesterol-fed rabbits. J Am Coll Cardiol 12, 1073-1078.   |  Medline